For years, SAM MOORE was best known for his work with the stirring soul duo SAM & DAVE. The rapid-file style built on the call and response of gospel fashioned by SAM MOORE while the trade mark able voice of the duo, sent several songs climbing up both the Pop and R & B charts including "Hold on I'm Comin", "I Thank You", "When Something Is Wrong With My Baby", "Soul Sister", "Brown Sugar", "Wrap It Up", and "Soul Man" (which SAM later recut with, of all people, Lou Reed for the soundtrack of the Steven Tisch movie of the same name.

SAM & DAVE, who played themselves in the Paul Simon movie "One Trick Pony" served as the inspiration for the parody by Belushi and Aykroyd of their Blues Brothers.

SAM was inducted into the Rock and Roll Hall Of Fame in 1992. He was asked to be one of the headliners for the HBO September 2, 1995 "Special" Live from Cleveland to celebrate the opening of the Hall Of Fame.